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Institute of Technology
Inventing Tomorrow

DNA scaffolding

The next frontier for information processing may lie at the interface of nanoelectronics and biotechnology.

An interdisciplinary team led by electrical and computer engineering professor Richard Kiehl is exploring the use of DNA as a programmable scaffolding for the self-assembly of nanoscale electronic components. As a model for fabricating and designing semiconductor devices and circuits, DNA offers two key advantages: size scale and programmability.

Most industry experts believe that within the next 10 to 15 years the ability to scale down conventional technologies will reach its limit. At that point, the operating principles of conventional devices—and the techniques used to fabricate them—will break down. The basic elements of the DNA molecule are at just the right scale, says Kiehl.

Self-assembly uses bio-recognition, a natural process in which one molecule is attracted to and binds with another to form small structures. In the case of DNA, the attraction can be programmed so that the molecules will spontaneously assemble in solution to achieve a desired result.

“It's possible to synthesize small versions of DNA molecules in the laboratory and program in whatever code you want,” says Kiehl. “And because the two strands of DNA have complementary codes that match up, you can design one strand of DNA in a certain way so it will match another strand and assemble a nanoscale structure this way."

The matched segments form a scaffolding on which nanoparticles are affixed at highly selective attachment points. It's an approach that offers the programmability and precision needed for assembling electronic circuitry on the nanoscale.

“We have to make a real paradigm shift,” Kiehl says. “Not only do we have to keep improving performance, but we also must look at the kinds of devices we can make at those scales and how we want to use them to process information."

To that end, the researchers are turning to the human brain for inspiration. They envision devices whose electrical characteristics resemble those of neuron-like electrical waveforms in the brain. Like certain regions of the brain, the devices would process information based on pattern recognition rather than on individual bits of information. It's a more sophisticated level of information processing than can be achieved using conventional computers.

Kiehl predicts there will be a wide range of applications for this technology, including signal processing, communications systems, and computer systems. “The higher end of this [work] will be things that computers can't do very well today because the operations they use are too restrictive. One is the ability to recognize a pattern, such as identifying a letter as being an 'A' or a 'B', or being able to identify a face.

“It won't be just making things faster and faster in the conventional way,” he says. “It will really be opening up new ways to process information in machines."